Is St Johns Wort Safe with Bupropion?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Do not combine. Inform your doctor or pharmacist before taking St. John's Wort with Bupropion. Discontinue St. John's Wort under medical supervision.
Why this interaction occurs
St. John's Wort (Hypericum perforatum) induces CYP2B6, the primary enzyme responsible for Bupropion metabolism, potentially reducing plasma levels and efficacy. Additionally, combining both agents may lower the seizure threshold and increase CNS stimulation risk.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 79,183 reports mentioning Bupropion. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Bupropion + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All St Johns Wort interactions → · All Bupropion interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.