Is Tobacco (Smoking) Safe with clozapine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Inform your doctor about your smoking status. If you start or stop smoking while on clozapine, notify your doctor immediately, as your clozapine dose may need to be adjusted to maintain effectiveness or avoid toxicity.
Why this interaction occurs
Tobacco smoke is identified as a moderate inducer of CYP1A2. Concomitant use can decrease plasma concentrations of clozapine, reducing its effectiveness. Discontinuation of smoking can result in increased clozapine plasma levels and an increased risk of adverse reactions, requiring dosage reduction.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 81,529 reports mentioning clozapine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the clozapine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Tobacco (Smoking) interactions → · All clozapine interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.