Is Caffeine Safe with clozapine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Monitor your caffeine intake (coffee, tea, energy drinks, supplements) while taking clozapine. Inform your doctor if you consume significant amounts of caffeine, as your clozapine dose may need adjustment.
Why this interaction occurs
Caffeine is identified as a moderate or weak CYP1A2 inhibitor. Concomitant use with clozapine can increase clozapine plasma levels, potentially resulting in adverse reactions. Close patient monitoring is recommended and a clozapine dosage reduction should be considered if necessary.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 81,529 reports mentioning clozapine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the clozapine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Caffeine interactions → · All clozapine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.