Is Tryptophan Safe with fluvoxamine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid combining tryptophan supplements with fluvoxamine. Consult your doctor before using tryptophan in any form while taking this medication.
Why this interaction occurs
Tryptophan may enhance the serotonergic effects of fluvoxamine, increasing the risk of serotonin syndrome. Severe vomiting has been reported with the coadministration of fluvoxamine and tryptophan.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 6,443 reports mentioning fluvoxamine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the fluvoxamine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Tryptophan interactions → · All fluvoxamine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.