Is Tryptophan Safe with mirtazapine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid taking tryptophan supplements while using mirtazapine. If you are currently taking it, inform your doctor immediately and monitor for symptoms of serotonin syndrome such as agitation, hallucinations, rapid heart rate, fever, muscle twitching, or diarrhea.
Why this interaction occurs
Concomitant use of serotonergic drugs, including tryptophan, with mirtazapine increases the risk of serotonin syndrome, particularly during treatment initiation and dosage increases.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 77,936 reports mentioning mirtazapine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the mirtazapine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Tryptophan interactions → · All mirtazapine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.