Is Turmeric (Curcuma longa extract) Safe with Amphotericin B?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Notify your healthcare provider if using turmeric supplements while receiving amphotericin B therapy. The combination showed in vitro synergy; clinical implications are unknown and concurrent use should be disclosed and monitored.
Why this interaction occurs
In vitro combination disc testing revealed synergistic antifungal activity between Curcuma longa ethanolic extract and amphotericin B against Candida species (p=0.05), with enhanced inhibition zones relative to either agent alone. Pharmacodynamic synergy at the clinical level is plausible but unconfirmed.
Evidence
Evidence level: limited.
Data source
PubMed - PMID 42409910
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 3,830,297 reports mentioning Amphotericin B. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Amphotericin B + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Turmeric (Curcuma longa extract) interactions → · All Amphotericin B interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.