Is Turmeric (Curcuma longa extract) Safe with Fluconazole?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Inform your healthcare provider if taking turmeric supplements alongside fluconazole. While synergy may enhance antifungal efficacy, dosage adjustments may be warranted to avoid unpredictable effects. Do not self-adjust fluconazole dosing.
Why this interaction occurs
In vitro data demonstrated statistically significant synergistic antifungal activity between Curcuma longa ethanolic extract and fluconazole against Candida species (p<0.001), resulting in enhanced inhibition zones compared to either agent alone. This pharmacodynamic synergy could theoretically alter expected drug efficacy or dose requirements in clinical use.
Evidence
Evidence level: limited.
Data source
PubMed - PMID 42409910
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 58,684 reports mentioning Fluconazole. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Fluconazole + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Turmeric (Curcuma longa extract) interactions → · All Fluconazole interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.