Is Valerian Safe with Buspirone?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Monitor for unusual drowsiness or dizziness. Inform your prescriber before starting valerian. Avoid driving until you know how this combination affects you.
Why this interaction occurs
While buspirone itself has low sedation potential, valerian's GABAergic modulation may produce additive CNS depression. There is limited but plausible pharmacodynamic interaction that could impair alertness in sensitive individuals.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 30,342 reports mentioning Buspirone. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Buspirone + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Valerian interactions → · All Buspirone interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.