Is Valerian Safe with Clonazepam?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Do not use valerian while taking clonazepam without medical supervision. Discuss with your prescriber before starting or stopping valerian, as abrupt discontinuation may cause rebound anxiety.
Why this interaction occurs
Valerian's GABAergic activity is pharmacodynamically additive with clonazepam. This combination heightens sedation, cognitive impairment, and risk of falls, particularly dangerous in patients on long-term clonazepam therapy.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 122,823 reports mentioning Clonazepam. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Clonazepam + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Valerian interactions → · All Clonazepam interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.