Is Vitamin C Safe with Febuxostat?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Vitamin C supplements up to 500mg/day are generally safe with febuxostat. Inform your doctor so uric acid levels can be appropriately tracked.
Why this interaction occurs
Similar to its interaction with allopurinol, vitamin C exerts mild uricosuric effects. Combined with febuxostat's potent xanthine oxidase inhibition, uric acid levels may drop further, which is usually beneficial but should be monitored.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 10,637 reports mentioning Febuxostat. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Febuxostat + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Vitamin C interactions → · All Febuxostat interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.