Is Vitamin C Safe with Colchicine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Limit vitamin C supplementation to doses under 1000mg/day and monitor for increased gastrointestinal side effects such as nausea or diarrhea when taken alongside colchicine.
Why this interaction occurs
High-dose vitamin C supplements can independently cause gastrointestinal upset. Combined with colchicine, which already irritates the GI tract, additive GI adverse effects such as diarrhea and nausea may be amplified.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 27,554 reports mentioning Colchicine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Colchicine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Vitamin C interactions → · All Colchicine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.