Is Vitamin D Safe with Montelukast?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Vitamin D supplementation within standard limits is safe with montelukast. Discuss optimal vitamin D dosing with your provider, particularly if you have poorly controlled asthma or allergic rhinitis.
Why this interaction occurs
Vitamin D modulates immune responses including those involving leukotrienes, which are the primary mediators targeted by montelukast. Research suggests vitamin D may reduce leukotriene production and enhance montelukast's anti-inflammatory effects. There is no known adverse pharmacokinetic interaction, but therapeutic synergy at the immunological level has been proposed.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 86,387 reports mentioning Montelukast. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Montelukast + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Vitamin D interactions → · All Montelukast interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.