Is Caffeine Safe with Montelukast?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Moderate caffeine supplement intake is generally acceptable with montelukast. Avoid very high-dose caffeine supplements as they may mildly influence drug metabolism.
Why this interaction occurs
Montelukast is primarily metabolized by CYP2C8 and CYP3A4 enzymes. High-dose caffeine supplements may modestly compete for CYP3A4 pathways, but at typical supplemental doses this interaction is unlikely to be clinically significant. The interaction is theoretical but worth noting in patients taking high-dose caffeine products.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 86,387 reports mentioning Montelukast. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Montelukast + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Caffeine interactions → · All Montelukast interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.