Is Vitamin D Safe with Rosuvastatin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Maintain adequate vitamin D levels (target 25-OH vitamin D: 30–50 ng/mL) while on rosuvastatin. Have vitamin D levels checked annually or if experiencing unexplained muscle pain. Supplementation with vitamin D3 1000–2000 IU/day may be appropriate if deficient.
Why this interaction occurs
Statins can reduce 25-hydroxyvitamin D levels through inhibition of the mevalonate pathway, which affects cholesterol-based precursors required for vitamin D synthesis. Vitamin D deficiency independently predisposes patients to muscle weakness and myalgia, potentially compounding statin-associated muscle symptoms. Optimizing vitamin D may reduce SAMS risk.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 115,467 reports mentioning Rosuvastatin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Rosuvastatin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Vitamin D interactions → · All Rosuvastatin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.