Is Vitamin K2 (Menaquinone) Safe with Ozempic?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Take Vitamin K2 supplements with a fat-containing meal. Maintain consistent intake to support bone and cardiovascular health.
Why this interaction occurs
Vitamin K2 is a fat-soluble vitamin absorbed via chylomicron packaging in the intestinal lymphatic system. Reduced fat consumption caused by appetite suppression from Ozempic can decrease K2 bioavailability. Adequate K2 is important for osteocalcin carboxylation and bone mineral density, which may already be a concern in patients on long-term GLP-1 therapy.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 66,161 reports mentioning Ozempic. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Ozempic + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Vitamin K2 (Menaquinone) interactions → · All Ozempic interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.