Is Zinc Safe with Furosemide?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Supplement with zinc 15–25 mg daily taken with food. Avoid zinc doses above 40 mg/day long-term without guidance. Monitor for zinc deficiency symptoms such as poor wound healing, taste changes, or frequent infections.
Why this interaction occurs
Loop diuretics increase renal zinc clearance through impaired tubular reabsorption. Long-term furosemide use in heart failure and edema patients is associated with clinically significant zinc depletion, which further compromises immune defense, antioxidant capacity (zinc is a cofactor for superoxide dismutase), and protein synthesis needed for cardiac tissue repair.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 274,011 reports mentioning Furosemide. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Furosemide + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Zinc interactions → · All Furosemide interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.