Is Bromelain Safe with Amoxicillin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Inform your prescribing physician if you are taking bromelain alongside amoxicillin. While this interaction may not be harmful, altered drug levels could affect therapeutic outcomes. Do not self-adjust antibiotic dosing based on perceived enhanced effect.
Why this interaction occurs
Clinical studies have demonstrated that bromelain can significantly increase plasma concentrations of amoxicillin by enhancing intestinal absorption and mucosal permeability. This pharmacokinetic interaction may increase antibiotic efficacy but could also increase the risk of dose-dependent side effects.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 115,001 reports mentioning Amoxicillin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Amoxicillin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Bromelain interactions → · All Amoxicillin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.