Is Bromelain Safe with Clopidogrel?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid taking bromelain supplements if you are prescribed clopidogrel. If combination is unavoidable, consult your cardiologist. Watch for and immediately report signs of excessive bleeding, including unusually heavy bruising, prolonged bleeding after cuts, or blood in urine or stool.
Why this interaction occurs
Clopidogrel irreversibly blocks P2Y12 ADP receptors on platelets, significantly reducing platelet aggregation. Bromelain adds further antiplatelet and fibrinolytic activity through independent pathways, creating a compounded bleeding risk that can be clinically significant, particularly in patients with cardiovascular disease.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 108,615 reports mentioning Clopidogrel. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Clopidogrel + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Bromelain interactions → · All Clopidogrel interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.