Is Caffeine Safe with duloxetine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Be aware that duloxetine may modestly increase caffeine levels in your body due to CYP1A2 inhibition. Monitor for increased caffeine-related effects such as jitteriness, insomnia, or rapid heartbeat if consuming caffeine regularly.
Why this interaction occurs
The FDA label notes that duloxetine is an inhibitor of CYP1A2 in vitro, and caffeine is listed as a CYP1A2 substrate. Inhibition of CYP1A2 may reduce caffeine metabolism, potentially increasing caffeine exposure, though no dedicated clinical study for caffeine specifically was performed.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 77,020 reports mentioning duloxetine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the duloxetine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Caffeine interactions → · All duloxetine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.