Is Calcium (intravenous) Safe with digoxin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid rapid intravenous administration of calcium supplements if taking digoxin. Notify your healthcare provider immediately if IV calcium is required in any clinical setting.
Why this interaction occurs
If administered rapidly by the intravenous route, calcium can produce serious arrhythmias in digitalized patients due to synergistic effects on cardiac conduction and contractility.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 64,171 reports mentioning digoxin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the digoxin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Calcium (intravenous) interactions → · All digoxin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.