Is Cannabidiol (CBD) Safe with sirolimus?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Inform your doctor before using any CBD products. If co-administered, sirolimus blood levels must be closely monitored and a dose reduction of sirolimus should be considered.
Why this interaction occurs
Concomitant use of cannabidiol with sirolimus may increase sirolimus blood levels, raising the risk of adverse reactions and sirolimus toxicity.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 14,104 reports mentioning sirolimus. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the sirolimus + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Cannabidiol (CBD) interactions → · All sirolimus interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.