Is Grapefruit Juice Safe with sirolimus?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Do not consume grapefruit juice at any time while taking sirolimus.
Why this interaction occurs
Grapefruit juice inhibits CYP3A4-mediated metabolism of sirolimus, leading to significantly increased sirolimus blood concentrations and risk of toxicity.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 14,104 reports mentioning sirolimus. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the sirolimus + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Grapefruit Juice interactions → · All sirolimus interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.