Is CoQ10 Safe with Digoxin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Inform your cardiologist if you wish to take CoQ10. Monitor for any changes in heart rhythm or symptoms of heart failure worsening. Do not start CoQ10 without medical approval.
Why this interaction occurs
CoQ10 has been reported in some case studies to reduce digoxin serum levels, potentially diminishing its therapeutic effect in heart failure and atrial fibrillation management. The mechanism may involve induction of intestinal P-glycoprotein, which reduces digoxin absorption. Clinical significance varies by individual.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 64,171 reports mentioning Digoxin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Digoxin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All CoQ10 interactions → · All Digoxin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.