Is CoQ10 Safe with Hydralazine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Inform your doctor if you take CoQ10 alongside hydralazine. Monitor blood pressure at home. CoQ10 has mild antihypertensive properties that could add to hydralazine's effect.
Why this interaction occurs
CoQ10 has demonstrated modest blood pressure-lowering effects in clinical trials, with reductions of approximately 10-17 mmHg systolic in some studies. Combined with hydralazine's vasodilatory action, there may be an additive hypotensive effect, though significant adverse outcomes are uncommon. Dose adjustment of hydralazine may rarely be needed.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 37,194 reports mentioning Hydralazine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Hydralazine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All CoQ10 interactions → · All Hydralazine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.