Is CoQ10 Safe with Progesterone (Prometrium, Endometrin, Crinone)?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
CoQ10 is generally considered safe alongside progesterone supplementation. No dose adjustment is typically needed. Continue standard progesterone monitoring protocols.
Why this interaction occurs
CoQ10 supports mitochondrial energy production in luteal phase endometrium and embryos. No pharmacokinetic interaction with exogenous progesterone is established. The combination may theoretically enhance endometrial receptivity, but evidence is limited to preclinical and observational studies.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 24,690 reports mentioning Progesterone (Prometrium, Endometrin, Crinone). This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Progesterone (Prometrium, Endometrin, Crinone) + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All CoQ10 interactions → · All Progesterone (Prometrium, Endometrin, Crinone) interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.