Is CoQ10 Safe with Losartan?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Monitor blood pressure when initiating CoQ10 supplementation alongside Losartan. Report persistent dizziness or unusual fatigue. CoQ10 is generally well-tolerated but inform your cardiologist or pharmacist of its use.
Why this interaction occurs
CoQ10 (ubiquinone) has been shown in several clinical trials to modestly reduce systolic and diastolic blood pressure through improvement of endothelial function and mitochondrial energy production. When combined with Losartan, a small additive antihypertensive effect is possible, though the magnitude is typically modest and may actually benefit patients not at blood pressure goal.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 196,849 reports mentioning Losartan. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Losartan + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All CoQ10 interactions → · All Losartan interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.