Is CoQ10 (Ubiquinone) Safe with Furosemide?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Consider CoQ10 supplementation at 100–200 mg daily with a fatty meal to improve absorption, particularly in heart failure patients on long-term furosemide. Discuss with your cardiologist or pharmacist before starting.
Why this interaction occurs
Furosemide has been associated with reduced CoQ10 levels through increased urinary loss and oxidative stress-mediated depletion. CoQ10 is critical for mitochondrial ATP synthesis and functions as a fat-soluble antioxidant. In heart failure patients — who already have reduced myocardial CoQ10 levels — further depletion via diuretic therapy may impair cardiac energy metabolism. Small clinical trials support CoQ10 supplementation in heart failure management.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 274,011 reports mentioning Furosemide. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Furosemide + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All CoQ10 (Ubiquinone) interactions → · All Furosemide interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.