Is CoQ10 (Ubiquinone) Safe with Hydrochlorothiazide?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Consider supplementing CoQ10 100–200 mg daily with a fat-containing meal to optimize absorption. Ubiquinol form may be preferred for older patients. Discuss with your prescriber, especially if experiencing fatigue or muscle weakness.
Why this interaction occurs
Thiazide diuretics have been shown to reduce plasma CoQ10 levels, possibly through oxidative stress-mediated depletion or interference with mevalonate pathway activity shared with statin mechanisms when co-prescribed. CoQ10 is essential for mitochondrial ATP production in cardiac and skeletal muscle. Depletion may worsen fatigue, reduce exercise tolerance, and impair antioxidant defense in cardiovascular patients already on multiple medications.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 215,975 reports mentioning Hydrochlorothiazide. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Hydrochlorothiazide + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All CoQ10 (Ubiquinone) interactions → · All Hydrochlorothiazide interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.