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Is Curcumin Safe with Fluoxetine?

⚠️ HIGH SEVERITY
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Fluoxetine Curcumin
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Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature

WHAT YOU NEED TO KNOW

Avoid combining Curcumin with Fluoxetine — Curcumin blocks the liver enzyme (CYP2C9) that processes Fluoxetine, potentially raising Fluoxetine levels to toxic range. Consult your doctor or pharmacist.

Evidence

Evidence level: moderate.

Reported safety data

The FDA’s adverse event reporting system (FAERS) has received 87,365 reports mentioning Fluoxetine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Fluoxetine + supplement combination on this page.

FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.

Frequently asked questions

Can I take Curcumin with Fluoxetine?
Avoid unless your doctor or pharmacist directs otherwise. Avoid combining Curcumin with Fluoxetine — Curcumin blocks the liver enzyme (CYP2C9) that processes Fluoxetine, potentially raising Fluoxetine levels to toxic range. Consult your doctor or pharmacist.

Related interactions

St. John's Wort and Fluoxetine Bacopa Monnieri and Fluoxetine Goldenseal and Fluoxetine Berberine and Fluoxetine Milk Thistle and Fluoxetine Ginkgo Biloba and Fluoxetine Vitamin B12 (Cobalamin) and Fluoxetine CoQ10 (Ubiquinone) and Fluoxetine

All Curcumin interactions →  ·  All Fluoxetine interactions →

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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.