Is Bacopa Monnieri Safe with Fluoxetine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Consult your pharmacist or doctor before combining. Monitor for increased fluoxetine side effects such as insomnia, anxiety, or GI upset, which may indicate altered drug levels.
Why this interaction occurs
Bacopa monnieri has shown inhibitory activity on CYP3A4 and CYP2D6 enzymes in vitro. Fluoxetine is a potent CYP2D6 inhibitor and CYP2D6 substrate. Concurrent use may alter fluoxetine or norfluoxetine plasma concentrations, potentially increasing adverse effects or reducing efficacy.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 87,365 reports mentioning Fluoxetine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Fluoxetine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Bacopa Monnieri interactions → · All Fluoxetine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.