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Is Curcumin Safe with Tolbutamide?

⚠️ HIGH SEVERITY
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Tolbutamide Curcumin
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Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature

WHAT YOU NEED TO KNOW

Avoid combining Curcumin with Tolbutamide — Curcumin blocks the liver enzyme (CYP2C9) that processes Tolbutamide, potentially raising Tolbutamide levels to toxic range. Consult your doctor or pharmacist.

Evidence

Evidence level: moderate.

Reported safety data

The FDA’s adverse event reporting system (FAERS) has received 459 reports mentioning Tolbutamide. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Tolbutamide + supplement combination on this page.

FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.

Frequently asked questions

Can I take Curcumin with Tolbutamide?
Avoid unless your doctor or pharmacist directs otherwise. Avoid combining Curcumin with Tolbutamide — Curcumin blocks the liver enzyme (CYP2C9) that processes Tolbutamide, potentially raising Tolbutamide levels to toxic range. Consult your doctor or pharmacist.

Related interactions

St. John's Wort and Tolbutamide Milk Thistle and Tolbutamide Ginkgo Biloba and Tolbutamide Curcumin and Warfarin Curcumin and Tamoxifen Curcumin and Apixaban (Eliquis) Curcumin and Atorvastatin Curcumin and Simvastatin

All Curcumin interactions →  ·  All Tolbutamide interactions →

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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.