Is Fish Oil Safe with Celecoxib?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Fish oil may be cautiously combined with celecoxib, but inform your doctor, especially if you have cardiovascular risk factors. Monitor blood pressure and report any unusual symptoms.
Why this interaction occurs
Celecoxib selectively inhibits COX-2, sparing COX-1-mediated platelet function, so bleeding risk with fish oil is lower than with non-selective NSAIDs. However, both agents affect eicosanoid pathways, and high-dose fish oil may modestly influence blood pressure and cardiovascular hemodynamics in at-risk patients.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 37,331 reports mentioning Celecoxib. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Celecoxib + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Fish Oil interactions → · All Celecoxib interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.