Is Fish Oil Safe with Naproxen?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid high-dose fish oil supplementation (>3g/day) while taking naproxen. If you must use both, discuss with your doctor and monitor for signs of bleeding such as dark stools or easy bruising.
Why this interaction occurs
Naproxen inhibits COX-1-dependent thromboxane A2 synthesis, impairing platelet aggregation. Omega-3 fatty acids in fish oil further suppress platelet function via reduced arachidonic acid availability. The combined antiplatelet effect meaningfully increases bleeding risk.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 96,214 reports mentioning Naproxen. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Naproxen + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Fish Oil interactions → · All Naproxen interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.