Is folate Safe with gabapentin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Monitor folate levels periodically during gabapentin therapy and consider folate supplementation (400–800 mcg/day) if levels are found to be low or deficient.
Why this interaction occurs
Antiepileptic drugs including gabapentin have been associated with reduced serum folate levels, potentially through interference with folate metabolism or absorption, which may increase risk of folate-related deficiencies.
Evidence
Evidence level: limited.
Data source
PubMed - PMID 21246600
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 299,859 reports mentioning gabapentin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the gabapentin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All folate interactions → · All gabapentin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.