Is vitamin B12 Safe with gabapentin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Monitor serum vitamin B12 levels periodically during long-term gabapentin use and consider B12 supplementation if levels fall below normal range, particularly in elderly patients or those with dietary restrictions.
Why this interaction occurs
Antiepileptic drug treatment has been associated with reduced serum vitamin B12 levels, potentially through effects on absorption or metabolism, which may contribute to neurological or hematological complications if left unaddressed.
Evidence
Evidence level: limited.
Data source
PubMed - PMID 21246600
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 299,859 reports mentioning gabapentin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the gabapentin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All vitamin B12 interactions → · All gabapentin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.