Is Magnesium Hydroxide / Aluminum Hydroxide (Maalox) Safe with gabapentin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Take gabapentin at least 2 hours after taking Maalox or other magnesium/aluminum hydroxide antacids.
Why this interaction occurs
Concomitant use of Maalox (containing magnesium and aluminum hydroxides) reduced the mean bioavailability of gabapentin by approximately 20%, potentially reducing its therapeutic effect.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 299,859 reports mentioning gabapentin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the gabapentin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Magnesium Hydroxide / Aluminum Hydroxide (Maalox) interactions → · All gabapentin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.