Is Folinic Acid (Leucovorin) Safe with methotrexate?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Take folinic acid only as directed by your healthcare provider. Do not self-supplement without medical guidance.
Why this interaction occurs
Coadministration of methotrexate with folic acid derivatives, including folinic acid, decreases the clinical effectiveness of methotrexate in patients with neoplastic diseases due to competition for active transport across cell membranes.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 499,559 reports mentioning methotrexate. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the methotrexate + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Folinic Acid (Leucovorin) interactions → · All methotrexate interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.