Is Nitrous Oxide (Laughing Gas) Safe with methotrexate?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid nitrous oxide anesthesia while receiving methotrexate. Inform all healthcare providers and dentists that you are taking methotrexate. Consider alternative anesthesia options.
Why this interaction occurs
Coadministration of methotrexate with nitrous oxide anesthesia potentiates the effect of methotrexate on folate-dependent metabolic pathways, which may increase the risk of severe methotrexate adverse reactions.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 499,559 reports mentioning methotrexate. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the methotrexate + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Nitrous Oxide (Laughing Gas) interactions → · All methotrexate interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.