Is Glycine Safe with Pregabalin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Disclose Glycine supplement use to your prescriber when taking Pregabalin. Avoid driving until the combined effect is known. Report unusual drowsiness or muscle weakness.
Why this interaction occurs
Pregabalin shares the alpha-2-delta mechanism of Gabapentin with greater potency. Glycine's inhibitory glycinergic receptor activity may add to Pregabalin's CNS depression profile. This is particularly relevant at higher Pregabalin doses used for sleep or anxiety, where the inhibitory burden may become clinically significant.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 80,713 reports mentioning Pregabalin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Pregabalin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Glycine interactions → · All Pregabalin interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.