Is Vitamin D Safe with Pregabalin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Maintain adequate vitamin D intake through diet or supplementation (600–1000 IU/day). If used long-term for neuropathic pain or epilepsy, periodic 25-OH vitamin D screening is a reasonable precaution.
Why this interaction occurs
Pregabalin does not induce CYP450 enzymes and has no direct pharmacokinetic interaction with vitamin D. However, limited data suggest that patients on pregabalin for chronic conditions may have higher rates of vitamin D insufficiency, potentially due to reduced mobility, sun exposure, or associated comorbidities rather than a direct drug effect.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 80,713 reports mentioning Pregabalin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Pregabalin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Vitamin D interactions → · All Pregabalin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.