Is Grapefruit Juice Safe with atorvastatin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid intake of large quantities of grapefruit juice (more than 1.2 liters daily) when taking atorvastatin.
Why this interaction occurs
Grapefruit juice consumption, especially excessive consumption of more than 1.2 liters daily, can raise the plasma levels of atorvastatin and may increase the risk of myopathy and rhabdomyolysis.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 343,939 reports mentioning atorvastatin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the atorvastatin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Grapefruit Juice interactions → · All atorvastatin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.