Is Grapefruit Juice Safe with buspirone?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid drinking large amounts of grapefruit juice while taking buspirone.
Why this interaction occurs
Coadministration of buspirone (10 mg single dose) with grapefruit juice (200 mL double-strength t.i.d. for 2 days) increased plasma buspirone concentrations 4.3-fold in C-max and 9.2-fold in AUC, likely due to inhibition of CYP3A4-mediated metabolism.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 30,342 reports mentioning buspirone. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the buspirone + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Grapefruit Juice interactions → · All buspirone interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.