Is Grapefruit Juice Safe with colchicine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid or limit grapefruit juice consumption while taking colchicine. Consult your healthcare provider before making changes.
Why this interaction occurs
Grapefruit juice (240 mL twice daily for 4 days) was studied in a pharmacokinetic interaction trial with colchicine 0.6 mg single dose (N=21). Results showed minimal mean changes in colchicine Cmax (-2.55%) and AUC (-2.36%), though individual variability ranged widely (-53.4% to 55.0% for Cmax and -46.4% to 62.2% for AUC). While the mean effect was negligible, the wide individual variability warrants caution given colchicine's narrow therapeutic index.
Evidence
Evidence level: strong.
Data source
FDA Drug Label (OpenFDA)
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 27,554 reports mentioning colchicine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the colchicine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Grapefruit Juice interactions → · All colchicine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.