Is Grapefruit Juice Safe with fentanyl?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid consuming grapefruit juice while receiving fentanyl. Inform your healthcare provider if you regularly consume grapefruit or grapefruit juice.
Why this interaction occurs
Grapefruit juice is a CYP3A4 inhibitor. Concomitant use with fentanyl can increase fentanyl plasma concentrations, resulting in increased or prolonged opioid effects including potentially serious respiratory depression and sedation.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 140,655 reports mentioning fentanyl. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the fentanyl + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Grapefruit Juice interactions → · All fentanyl interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.