Is Green Coffee Extract Safe with Glipizide?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid combining without physician approval. If used together, increase blood glucose monitoring frequency. Carry fast-acting glucose source. Notify your doctor immediately if blood sugar drops below 70 mg/dL.
Why this interaction occurs
Sulfonylureas like glipizide stimulate insulin secretion. Green coffee extract further lowers blood glucose through chlorogenic acid-mediated inhibition of hepatic glucose production and intestinal glucose absorption, significantly elevating hypoglycemia risk.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 55,328 reports mentioning Glipizide. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Glipizide + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Green Coffee Extract interactions → · All Glipizide interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.