Is GLA Evening Primrose Oil Safe with Glipizide?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Monitor blood sugar levels carefully when combining Evening Primrose Oil with sulfonylureas. Report unexpected hypoglycemia or loss of glucose control to your prescriber.
Why this interaction occurs
GLA metabolites influence prostaglandin E1 pathways that affect insulin secretion and peripheral glucose uptake. This may alter the predictability of glycemic control in patients on sulfonylurea therapy.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 55,328 reports mentioning Glipizide. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Glipizide + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All GLA Evening Primrose Oil interactions → · All Glipizide interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.