Is Bilberry Safe with Glipizide?
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Exercise caution when combining bilberry with sulfonylureas like glipizide. Check blood sugar levels regularly and be alert to hypoglycemia symptoms. Discuss supplementation with your endocrinologist before starting.
Why this interaction occurs
Bilberry extracts have shown glucose-lowering activity that, when combined with sulfonylureas which already stimulate insulin secretion, may significantly increase the risk of hypoglycemia. This interaction is of particular concern in elderly patients with reduced hypoglycemia awareness.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 55,328 reports mentioning Glipizide. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Glipizide + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Bilberry interactions → · All Glipizide interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.