Is Histamine-containing foods (skipjack, tuna, tropical fish) Safe with isoniazid?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid histamine-containing foods such as skipjack, tuna, and other tropical fish while taking isoniazid.
Why this interaction occurs
Isoniazid inhibits diamine oxidase, causing an exaggerated response to histamine-containing foods, including symptoms such as headache, sweating, palpitations, flushing, and hypotension.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 17,281 reports mentioning isoniazid. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the isoniazid + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Histamine-containing foods (skipjack, tuna, tropical fish) interactions → · All isoniazid interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.