Is Iron Safe with Colchicine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Take iron supplements at least 2 hours before or 4 hours after colchicine to minimize absorption interference.
Why this interaction occurs
Colchicine can impair intestinal absorption of iron by damaging the gastrointestinal mucosa and reducing active transport mechanisms in the small intestine with prolonged use.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 27,554 reports mentioning Colchicine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Colchicine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Iron interactions → · All Colchicine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.