Is Magnesium Safe with Colchicine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid high-dose magnesium supplements (especially magnesium oxide or citrate) while taking colchicine. If magnesium supplementation is needed, use lower doses and inform your physician if diarrhea worsens.
Why this interaction occurs
Colchicine frequently causes dose-dependent diarrhea and GI toxicity. Magnesium supplements, particularly magnesium oxide and citrate, have well-known osmotic laxative effects. The combination can significantly worsen diarrhea, increasing the risk of dehydration and electrolyte imbalances.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 27,554 reports mentioning Colchicine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Colchicine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Magnesium interactions → · All Colchicine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.